Serum procalcitonin and C reactive protein as early detectors of anatomotic leakage.
DOI:
https://doi.org/10.31837/cir.urug/2.2.1Keywords:
suture, calprotectin, c reactive protein, anastomotic leackageAbstract
Anastomotic leakage in digestive sutures determines high morbidity and mortality, but its early diagnoses is critical and controversial. There is an important interest on finding an early detection biomarker that allows early diagnoses without clinical evidences. Many studies have shown the eficacy of Procalcitonin (PCT) and C Reactive Protein (CRP) as early detection biomarkers of anastomotic leackeage, as they were demostrated as useful intraabdominal infection predictors. This prospective observational study took place in Hospital Maciel, Department of Surgery nº 3, in a period of 14 months, and included all patients undergoing elective surgery with a digestive suture. CRP and PCT were measured preoperatively and on postoperative days (POD) 1, 2, 3, 4, 5 and patients were followed for postoperative complications with the aim to determine if they were suitable as anastomotic leackage monitoring tool in the postoperative setting. We established two groups: with and without anastomotic leackage.
28 patients were included. 14,3% corresponded to the anastomotic leackage group with a mortality of 3,6%. We found a statistically significative increase of both biomarkers in the leackage group (CRP p=0,001 and PCT p=0,003) with a remarkable increase specially POD 3. The main limitation of the study is the small number of patients. There was no statistically difference in demographic characteristics between groups. According to our results, postoperative PCT and CRP determination can be use as adecuated early predictors of anastomotic
leackage from the POD 2.
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