Gastrointestinal stromal tumors (GIST)
Keywords:
Gastointestinal stromal tumorsAbstract
The term gastointestinal stromal tumor (GIST)
is used to detemine the most common type of
mesenchymal tumor of the gastrointestinal tract;
they are apt to appear anywhere within the gastrointestinal
tract and at times in the mesente.
This paper is an update of a topic of increasing
interest in our scenaío and one that presents diículties
as to diagnosis equiring immunohistochemical
techniques to categorize it. Pogress as to
its genetic data has rendered possible identiying
a speciic molecular anomaly and, simultaneousl,
the speciic drug for this anomaly.
These tumors represent a paticular nosologic
entit, as fom the discovey in 1998 of the manifestation
of a mutated receptor of tirosinchinase
(e-KIT) in the fusiform ce/Is of which they are composed.
Notwithstanding speciiciy of CD 117 for the purpose
of diagnosis, there st1 rema in a 1 % of these
tumors, which are CD 117 negative, therefore in
order to diagnose them morphologic identiication
by an epert pahologist is required.
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