The place of the carcinoembryonic antigen (CEA) in a diagnostic strategy and treatment of patients with colorectal cancer
An ongoing clinical experience
Keywords:
colorectal cancerAbstract
The authors analyse the clinical utility of CEA in the
diagnosis, prognosis. and treatment of patients with
colorrectal cancer. as regards their personal experience
w1th a systematic protocol which includes preoperative
dosage and serial postoperative dosage every 3 months.
This analysis shows: a) the poor utility of CEA as a
diagnostic method beca use of its low sensitivity (50. 8%). b)
The 1mportance of h1gh preoperative CEA in Dukes 8 and
C stages as a bad prognosis sign, and specially the
absence of post--operative decrease to normal figures in
those cases resected with curative intention. e) The high
effect1V1ty of permanent postoperative CEA rise for
detection of tumoral reccurrence with a sensitivity of 84%
and a negilg1ble number of false positives.
The_ir_sti/1 limited exeprience prevents them from giving
an op,n1o_n on the most conflictive issue: this sensitivity·s
contnbut1on towards the achievement of an effective
treatment of the so--diagnosed reccurrences.
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