Mortality factors in acute septic cholangitis
Keywords:
Cholangitis, sepsis, mortalityAbstract
The mortality of acute septic cholangitis (CAS) continues to be high in Uruguay despite its significant decline in recent years. The objective of the present study is to establish the determinants of mortality in patients with CAS; from a retrospective record of 10 years. Sixty-seven patients were studied, 33% entered into septic shock, Klebsiella BLEE developed in 50% of cases and ampicillin sulbactam was empirically indicated in 59% with a mean time of 4 days of biliary drainage. Mortality in the series was 37%. Statistically significant factors for mortality were: age (greater than 65 years), initial shock, male gender, and time interval prior to biliary deobstruction. Statistically significant factors associated with mortality are: age greater than 65 years, initial shock, male sex and time interval before biliary deobstruction. Late degra- vation of the biliary tract and the empirical use of low-efficacy antibiotics are factors associated with an unfavorable outcome. The use of minimally invasive surgical techniques is associated with better survival.
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